(S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
CAS No.:1313580-19-6
Molecular Formula:C₂₆H₂₅ClN₄O₄
Molecular Weight:492.962
Hs Code.:

Synonyms:(S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

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Chemical Property of (S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

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Technology Process of (S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

There total 8 articles about (S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1313580-18-5
(S)-methyl 2-(6-(5-aminopyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

: 3320-83-0
o-chlorophenyl isocyanate

: 1313580-19-6
(S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1313580-19-6
(S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 8 steps

1: bromine; iron / 16 h / 0 - 20 °C

2: thionyl chloride / 0 - 20 °C

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 80 °C

4: triethylamine / toluene / 16 h / Reflux

5: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 70 - 120 °C / Inert atmosphere

6: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

7: iron; ammonium chloride / ethanol; water / 16 h / Reflux

8: tetrahydrofuran / 20 °C

With N-Bromosuccinimide; thionyl chloride; bromine; potassium acetate; iron; sodium carbonate; ammonium chloride; triethylamine; dibenzoyl peroxide; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 79669-50-4
methyl 2-methyl-5-bromobenzoate

: 1313580-19-6
(S)-methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 80 °C

2: triethylamine / toluene / 16 h / Reflux

3: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 70 - 120 °C / Inert atmosphere

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere

5: iron; ammonium chloride / ethanol; water / 16 h / Reflux

6: tetrahydrofuran / 20 °C

With N-Bromosuccinimide; potassium acetate; iron; sodium carbonate; ammonium chloride; triethylamine; dibenzoyl peroxide; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene;