(1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

Base Information

Chemical Name:(1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane
CAS No.:432504-76-2
Molecular Formula:C₁₅H₁₉NO₂
Molecular Weight:245.321
Hs Code.:

Synonyms:(1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

Suppliers and Price of (1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

There total 1 articles about (1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221196-91-4
(S)-2-(chloromethyl)-4-isopropyl-4,5-dihydrooxazole

: 432504-76-2
(1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA; Ti(i-PrO)4 / tetrahydrofuran / -98 °C

1.2: 50 percent / tetrahydrofuran

2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / -98 °C

2.2: 50 percent / tetrahydrofuran; cyclohexane

With titanium(IV) isopropylate; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane;
DOI:10.1021/ol025781i

Reference yield: 70.0%

: 432504-76-2
(1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

: 119-61-9
benzophenone

: 432504-77-3
(3S,5S,8R,9S)-3-isopropyl-9-methyl-7,7,8-triphenyl-8,9-epoxy-1,6-dioxa-4-azaspiro[4.4]nonane

Guidance literature:: (1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -98 ℃;

benzophenone; In diethyl ether; cyclohexane; Further stages.;
DOI:10.1021/ol025781i

Reference yield: 65.0%

: 432504-76-2
(1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane

: 3376-24-7,52392-70-8,85225-53-2,68315-30-0
(Z)-N-benzylidene-2-methylpropan-2-amine oxide

: 914489-92-2
(3S,5R,8S,9S,10S)-N-tert-butyl-3-isopropyl-10-methyl-8,9-diphenyl-9,10-epoxy-1,6-dioxa-4,7-diazaspiro[4,5]decane

Guidance literature:: (1R,2S,4S')-(+)-2-(4-isopropyl-2-oxazolin-2-yl)-1-phenyl-1,2-epoxypropane; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

(Z)-N-benzylidene-2-methylpropan-2-amine oxide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/ol0618609