ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

Base Information

Chemical Name:ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate
CAS No.:1202056-86-7
Molecular Formula:C₂₇H₃₀F₃N₇O₄
Molecular Weight:573.575
Hs Code.:

ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

Synonyms:ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

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Chemical Property of ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

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Technology Process of ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

There total 3 articles about ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 802535-77-9
ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

: 1001346-04-8
4-amino-N-(1-methylpiperidin-4-yl)-3-(trifluoromethoxy)benzamide

: 1202056-86-7
ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

Guidance literature:: With potassium carbonate; palladium diacetate; (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene; In N,N-dimethyl-formamide; at 70 ℃; for 8h; Inert atmosphere;

Reference yield:

: 802534-49-2
ethyl 8-amino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

: 1202056-86-7
ethyl 1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; iodine; cesium iodide; isopentyl nitrite / 1,2-dimethoxyethane / 3 h / 65 - 70 °C / Inert atmosphere

2: potassium carbonate / palladium diacetate; (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene / N,N-dimethyl-formamide / 8 h / 70 °C / Inert atmosphere

With copper(l) iodide; iodine; potassium carbonate; cesium iodide; isopentyl nitrite; palladium diacetate; (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;