4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one

Base Information

Chemical Name:4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one
CAS No.:109229-01-8
Molecular Formula:C₁₉H₂₂FN₃O₂
Molecular Weight:343.401
Hs Code.:

Synonyms:4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one

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Chemical Property of 4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one

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Technology Process of 4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one

There total 3 articles about 4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 109229-19-8
4-Hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid ethyl ester

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 109229-01-8
4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: With sodium carbonate; In toluene; for 100h; Heating;

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 109229-01-8
4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / K₂CO₃ / H₂O / 40 °C

2: 45 percent / toluene / 5 h / Heating

3: 44 percent / Na₂CO₃ / toluene / 100 h / Heating

With sodium carbonate; potassium carbonate; In water; toluene;

Reference yield:

: 1047-48-9
2-Phenyl-4-hydroxy-6-benzyl-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin

: 109229-01-8
4-(2-Ethyl-4-hydroxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / toluene / 5 h / Heating

2: 44 percent / Na₂CO₃ / toluene / 100 h / Heating

With sodium carbonate; In toluene;