R-(+)-1-(9-FLUORENYL)ETHANOL

Base Information

• Chemical Name: R-(+)-1-(9-FLUORENYL)ETHANOL
• CAS No.: 107474-78-2
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.276
• Mol file: 107474-78-2.mol

Synonyms:9H-Fluorene-9-methanol,a-methyl-, (R)-;(+)-1-(9-Fluorenyl)ethanol

Chemical Property of R-(+)-1-(9-FLUORENYL)ETHANOL

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (+)-1-(9-Fluorenyl)ethanol is an analytical reagent used in the separation of enantiomers of α-hydroxy acids by reversed-phase liquid chromatography after derivatization with 1-(9-fluorenyl)ethyl chloroformate.

Technology Process of R-(+)-1-(9-FLUORENYL)ETHANOL

There total 35 articles about R-(+)-1-(9-FLUORENYL)ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

9-acetylfluorene (3300-10-5) → (S)-1-(9H-fluoren-9-yl)ethan-1-ol (107474-78-2,151775-20-1)

Guidance literature:

With formic acid; N-[(1R,2R)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine; at 40 ℃; for 14h; Inert atmosphere;

DOI:10.1016/j.tet.2019.130591

Reference yield: 62.0%

9-acetylfluorene (3300-10-5) → 9-(1-hydroxyethyl)fluorene (3023-49-2,107474-78-2,151775-20-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 5 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.07.005

Reference yield: 23.0%

9-acetylfluorene (3300-10-5) → (R)-1-(9H-fluoren-9-yl)ethan-1-ol (107474-78-2,151775-20-1)

Guidance literature:

With lithium aluminium tetrahydride; (R)-(-)-2-(2-iso-indolinyl)butan-1-ol; In diethyl ether; at -15 ℃; for 24h;

DOI:10.1016/0957-4166(96)00245-5

upstream raw materials:

9-ethylfluorene

9-acetylfluorene

fluoren-9-ylmagnesium bromide

acetaldehyde

Downstream raw materials:

(R)-(+)-1,9-fluorenylethylchloroformate

(1R)-(+)-1-(9H-fluoren-9-yl)ethyl acetate

(S)-1-(9H-fluoren-9-yl)ethan-1-ol

(R)-1-(9H-fluoren-9-yl)ethan-1-ol

Refernces

• 1、 Ruzicka, Jan,Leyva, Elisa,Platz, Matthew S.. "Laser flash photolysis of 9-diazofluorene in low-temperature glasses". . p. 897 - 905. Retrieved 1992.
• 2、 Borowiecki, Pawel,Balter, Sylwia,Justyniak, Iwona,Ochal, Zbigniew. "First chemoenzymatic synthesis of (R)- and (S)-1-(9H-fluoren-9-yl)ethanol". . p. 1120 - 1126. Retrieved 2013/10/08.
• 3、 Brown, Eric,Leze, Antoine,Touet, Joel. "Synthesis of chiral alcohols by asymmetric reductions of various ketones including α-aminophenones". . p. 2029 - 2040. Retrieved 2007/10/03.