(2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: (2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester
• CAS No.: 769969-37-1
• Molecular Formula: C₂₇H₄₇N₃O₉P₂
• Molecular Weight: 619.632

Synonyms:(2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester

Chemical Property of (2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester

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Technology Process of (2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester

There total 1 articles about (2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

({2-[(diethoxyphosphorylmethyl)amino]ethylamino}methyl)phosphonic acid diethyl ester (87753-46-6) + (2R,5S)-1-benzylpyrrolidine-2,5-dicarboxylic acid 2-ethyl ester (183996-21-6) → (2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester (769969-37-1)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield: 78.3%

6-tert-butoxycarbonylamino-2-trifluoromethansulfonyloxy-hexanoic acid benzyl ester (769969-66-6) + (2R,5S)-1-benzyl-5-((diethoxyphosphorylmethyl)-{2-[(diethoxy-phosphorylmethyl)amino]-ethyl}carbamoyl)-pyrrolidine-2-carboxylic acid ethyl ester (769969-37-1) → (1'R,2R,5S)-1-benzyl-5-[{2-[(1-benzyloxycarbonyl-5-tert-butoxycarbonylaminopentyl)-(diethoxyphosphorylmethyl)amino]ethyl}(diethoxyphosphorylmethyl) carbamoyl]pyrrolidine-2-carboxylic acid ethyl ester (769969-38-2)

Guidance literature:

In dichloromethane; at -20 - 20 ℃; for 2h;

upstream raw materials:

({2-[(diethoxyphosphorylmethyl)amino]ethylamino}methyl)phosphonic acid diethyl ester

(2R,5S)-1-benzylpyrrolidine-2,5-dicarboxylic acid 2-ethyl ester

Downstream raw materials:

(1'R,2R,5S)-1-benzyl-5-[{2-[(1-benzyloxycarbonyl-5-tert-butoxycarbonylaminopentyl)-(diethoxyphosphorylmethyl)amino]ethyl}(diethoxyphosphorylmethyl) carbamoyl]pyrrolidine-2-carboxylic acid ethyl ester

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