2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

Base Information

Chemical Name:2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester
CAS No.:1206514-49-9
Molecular Formula:C₃₅H₄₃N₂O₉P
Molecular Weight:666.708
Hs Code.:

2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

Synonyms:2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

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Chemical Property of 2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

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Technology Process of 2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

There total 8 articles about 2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1206514-68-2
2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxyethoxycarbonylamino)ethyl]phosphinoyl}propionic acid

: 5557-81-3,5557-83-5,34404-37-0
alanine benzyl ester hydrochloride

: 1206514-49-9
2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

Reference yield:

: 115369-84-1
α-methylene-(1,1'-biphenyl)-4-propanoic acid

: 1206514-49-9
2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 15 h / 80 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / 5 h / 70 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

3.2: pH 1

4.1: hydrogen bromide; acetic acid / 1 h / 20 °C

5.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; water; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 115369-83-0
<(1,1'-biphenyl)-4-ylmethyl>propanedioic acid

: 1206514-49-9
2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethylamine / tetrahydrofuran / 20 h / Reflux

2.1: potassium carbonate / acetonitrile / 15 h / 80 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide / 5 h / 70 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

4.2: pH 1

5.1: hydrogen bromide; acetic acid / 1 h / 20 °C

6.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; water; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; diethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;