isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

Base Information

Chemical Name:isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester
CAS No.:1206596-94-2
Molecular Formula:C₄₁H₅₃N₂O₁₁P
Molecular Weight:780.852
Hs Code.:

Synonyms:isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

Suppliers and Price of isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

There total 9 articles about isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206514-49-9
2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

: 84674-32-8
1-isobutyric acid chloromethyl ester

: 1206596-94-2
isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; tetra(n-butyl)ammonium hydrogensulfate; sodium iodide; In toluene; at 120 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1206514-67-1
1-[(3-biphenyl-4-yl-2-carboxy-propyl)hydroxy-phosphinoyl]ethyl ammonium hydrobromide

: 1206596-94-2
isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetra(n-butyl)ammonium hydrogensulfate; sodium iodide / toluene / 3 h / 120 °C / Inert atmosphere

With sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; tetra(n-butyl)ammonium hydrogensulfate; sodium iodide; In water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 115369-83-0
<(1,1'-biphenyl)-4-ylmethyl>propanedioic acid

: 1206596-94-2
isobutyric acid 1-{1-[2-(1-benzyloxycarbonyl-isobutyryloxy-ethoxy)phosphinoyl]ethylcarbamoyloxy}ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethylamine / tetrahydrofuran / 20 h / Reflux

2.1: potassium carbonate / acetonitrile / 15 h / 80 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide / 5 h / 70 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

4.2: pH 1

5.1: hydrogen bromide; acetic acid / 1 h / 20 °C

6.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / tetra(n-butyl)ammonium hydrogensulfate; sodium iodide / toluene / 3 h / 120 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; water; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; diethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile;