N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide

Base Information

Chemical Name:N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide
CAS No.:1149359-64-7
Molecular Formula:C₂₃H₂₁N₃OS
Molecular Weight:387.505
Hs Code.:

Synonyms:N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide

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Chemical Property of N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide

Chemical Property:

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Technology Process of N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide

There total 4 articles about N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1149360-36-0
methyl 4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxylate

: 108-69-0
3,5-dimethylaminoaniline

: 1149359-64-7
N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide

Guidance literature:: With trimethylaluminum; In hexane; toluene; for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2011.01.063

Reference yield:

: 70199-58-5
4-(mercaptomethyl)pyridine hydrochloride

: 1149359-64-7
N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 20 - 90 °C

2: trimethylaluminum / hexane; toluene / 4 h / Inert atmosphere; Reflux

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trimethylaluminum; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; hexane; toluene;
DOI:10.1016/j.bmcl.2011.01.063

Reference yield:

: 942-24-5
3-methoxycarbonylindole

: 1149359-64-7
N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thallium(III) trifluoroacetate / trifluoroacetic acid / 2 h / 20 °C

1.2: 20 °C

2.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 20 - 90 °C

3.1: trimethylaluminum / hexane; toluene / 4 h / Inert atmosphere; Reflux

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trimethylaluminum; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; thallium(III) trifluoroacetate; In 1,4-dioxane; hexane; toluene; trifluoroacetic acid;
DOI:10.1016/j.bmcl.2011.01.063