Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester
• CAS No.: 791761-43-8
• Molecular Formula: C₁₈H₁₇F₄NO₃S
• Molecular Weight: 403.397
• Mol file: 791761-43-8.mol

Synonyms:Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester

Chemical Property of Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester

There total 2 articles about Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyl-((R)-5-fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine; hydrochloride → Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester (791761-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.68 g / 48percent aq. HBr / 7 h / 120 °C

2: 1.) K₂CO₃, Et₃N / 1.) CH₂Cl₂, reflux, 1 h, 2.) CH₂Cl₂, reflux, 22 h

With hydrogen bromide; potassium carbonate; triethylamine;

DOI:10.1021/jm960350p

Reference yield:

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + (R)-7-Benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-ol; hydrobromide → Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester (791761-43-8)

Guidance literature:

With potassium carbonate; triethylamine; Multistep reaction; 1.) CH₂Cl₂, reflux, 1 h, 2.) CH₂Cl₂, reflux, 22 h;

DOI:10.1021/jm960350p

Reference yield:

Trifluoro-methanesulfonic acid (R)-7-benzylamino-4-fluoro-5,6,7,8-tetrahydro-naphthalen-1-yl ester (791761-43-8) → Benzyl-((R)-5-fluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine (776273-79-1)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; formic acid; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1021/jm960350p

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

Downstream raw materials:

Benzyl-((R)-5-fluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine