7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene

Base Information

Chemical Name:7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene
CAS No.:908254-94-4
Molecular Formula:C₃₂H₃₄NO₆P
Molecular Weight:559.599
Hs Code.:

Synonyms:7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene

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Chemical Property of 7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene

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Technology Process of 7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene

There total 3 articles about 7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 908254-93-3
8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-9-en-7-one

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 908254-94-4
7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene

Guidance literature:: 8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-9-en-7-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/jo0607360

Reference yield:

: 854280-06-1
8-(tert-butoxycarbonyl)-7,9-dioxo-8-azaspiro[4.5]decane

: 908254-94-4
7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiHMDS / tetrahydrofuran / 1.5 h / -78 °C

1.2: 74 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 77 percent / Na₂CO₃ / PdCl₂(PPh₃)2 / tetrahydrofuran; H₂O; ethanol / 2 h / Heating

3.1: LiHMDS / tetrahydrofuran / 1.5 h / -78 °C

3.2: 78 percent / tetrahydrofuran / 2 h / -78 °C

With sodium carbonate; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; water; 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo0607360

Reference yield:

: 908254-92-2
9-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-9-en-7-one

: 908254-94-4
7-[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-9-phenyl-8-azaspiro[4.5]deca-6,9-diene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / Na₂CO₃ / PdCl₂(PPh₃)2 / tetrahydrofuran; H₂O; ethanol / 2 h / Heating

2.1: LiHMDS / tetrahydrofuran / 1.5 h / -78 °C

2.2: 78 percent / tetrahydrofuran / 2 h / -78 °C

With sodium carbonate; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; water; 1.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo0607360