Quinoline, 6-fluoro-5-methyl- (9CI)

Base Information

• Chemical Name: Quinoline, 6-fluoro-5-methyl- (9CI)
• CAS No.: 107224-22-6
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.179
• Mol file: 107224-22-6.mol

Synonyms:Quinoline, 6-fluoro-5-methyl- (9CI)

Chemical Property of Quinoline, 6-fluoro-5-methyl- (9CI)

Chemical Property:

• PSA: 12.89000
• LogP: 2.68230

Purity/Quality:

6-Fluoro-5-methylquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 6-fluoro-5-methyl- (9CI)

There total 2 articles about Quinoline, 6-fluoro-5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-fluoroquinoline (396-30-5) → 6-fluoro-5-methylquinoline (107224-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 26.1 percent / AlCl₃, Br₂ / 1,2-dichloro-ethane / 1.) 45 to 50 deg C, 2 h, 2.) reflux, 3 h

2: 1.) n-BuLi / 1.) THF, ether, hexane, -78 deg C, 15 min, 2.) THF, ether, hexane, 15 min

With n-butyllithium; aluminium trichloride; bromine; In 1,2-dichloro-ethane;

DOI:10.1021/jm00388a016

Reference yield:

5-bromo-6-fluoroquinoline (107224-21-5) + methyl iodide (74-88-4) → 6-fluoro-5-methylquinoline (107224-22-6)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) THF, ether, hexane, -78 deg C, 15 min, 2.) THF, ether, hexane, 15 min;

DOI:10.1021/jm00388a016

upstream raw materials:

5-bromo-6-fluoroquinoline

methyl iodide

6-fluoroquinoline

Refernces