t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate

Base Information

Chemical Name:t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate
CAS No.:502158-17-0
Molecular Formula:C₂₇H₄₁N₃O₇
Molecular Weight:519.638
Hs Code.:

Synonyms:t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate

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Chemical Property of t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate

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Technology Process of t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate

There total 7 articles about t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 144412-03-3
(Piperidin-4-yloxy)-acetic acid tert-butyl ester

: 502158-16-9
N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanine

: 502158-17-0
t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate

Guidance literature:: With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 26h;
DOI:10.1016/S0045-2068(02)00013-5

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 502158-17-0
t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / triethylamine / CH₂Cl₂ / 17 h / 0 - 25 °C

2: 90 percent / tetra-n-butylammonium hydrogen sulfate; NaOH / toluene; H₂O / 20 h

3: 100 percent / H₂ / 10 percent Pd/C / methanol / 4.5 h / 20 °C

4: 57 percent / HBTU; N-methylmorpholine / dimethylformamide / 26 h / 0 - 25 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0045-2068(02)00013-5

Reference yield:

: 95798-23-5
1-(benzyloxycarbonyl)-4-hydroxypiperidine

: 502158-17-0
t-butyl 2-[[1-[N-[4-[(tert-butoxycarbonylamino)methyl]benzoyl]alanyl]-4-piperidinyl]oxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / tetra-n-butylammonium hydrogen sulfate; NaOH / toluene; H₂O / 20 h

2: 100 percent / H₂ / 10 percent Pd/C / methanol / 4.5 h / 20 °C

3: 57 percent / HBTU; N-methylmorpholine / dimethylformamide / 26 h / 0 - 25 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0045-2068(02)00013-5