4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester

Base Information

Chemical Name:4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester
CAS No.:223787-44-8
Molecular Formula:C₁₂H₁₈NO₆P
Molecular Weight:303.252
Hs Code.:

Synonyms:4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester

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Chemical Property of 4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester

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Technology Process of 4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester

There total 4 articles about 4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 57559-52-1
4-methoxy-2-nitrobenzyl bromide

: 122-52-1
triethyl phosphite

: 223787-44-8
4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester

Guidance literature:: In toluene; at 120 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol400137q

Reference yield:

: 17484-36-5
4-Methyl-3-nitroanisole

: 223787-44-8
4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NBS; benzoyl peroxide / CCl₄

2: 69 percent / toluene / 5 h / Heating

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; toluene; 2: Arbuzov reaction;
DOI:10.1016/S0968-0896(02)00343-7

Reference yield:

: 33844-21-2
2-nitro-4-methoxybenzoic acid

: 223787-44-8
4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere

2: phosphorus tribromide / diethyl ether / 3 h / Inert atmosphere

3: toluene / 24 h / 120 °C / Inert atmosphere

With dimethylsulfide borane complex; phosphorus tribromide; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/ol400137q