33844-21-2

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Methoxy-2-nitrobenzoic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with diverse therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 4-Methoxy-2-nitrobenzoic acid is used as a building block for the creation of compounds that can enhance crop protection and yield.
Used in Dye Manufacturing:
4-Methoxy-2-nitrobenzoic acid is utilized as a component in the production of dyes, contributing to the colorfastness and vibrancy of various products.
Used in the Production of Optical Brightening Agents:
4-Methoxy-2-nitrobenzoic acid is used as a precursor in the synthesis of optical brightening agents, which are essential for enhancing the appearance of textiles, paper, and other materials.
Used in UV Stabilizer Production:
4-Methoxy-2-nitrobenzoic acid is employed in the creation of UV stabilizers, which are crucial for protecting materials from the degrading effects of ultraviolet radiation.
Used in the Development of New Materials:
4-Methoxy-2-nitrobenzoic acid has potential applications in the development of innovative materials, where its unique properties can be harnessed to create advanced products with improved performance characteristics.
Used in Chemical Manufacturing Processes:
As a valuable intermediate, 4-Methoxy-2-nitrobenzoic acid plays a critical role in various chemical manufacturing processes, facilitating the production of a wide range of chemical products.

InChI:InChI=1/C8H7NO5/c1-14-5-2-3-6(8(10)11)7(4-5)9(12)13/h2-4H,1H3,(H,10,11)

Upstream product

• 38469-83-9 4-methoxy-2-nitro-benzonitrile 
• 181871-73-8 methyl 4-methoxy-2-nitrobenzoate 
• 446-09-3 2-bromo-5-fluoronitrobenzene 
• 364-78-3 2-nitro-4-fluoroaniline 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 555-03-3 3-nitroanisole 
• 130017-52-6 5-acetylamino-4-methoxy-2-nitrobenzoic acid 
• 130017-51-5 3-acetamido-4-methoxybenzoic acid 
• 204254-70-6 5-amino-4-methoxy-2-nitro-benzoic acid 
• 101080-02-8 1-(chloromethyl)-4-methoxy-2-nitrobenzene 
• 127-09-3 sodium acetate 
• 17484-36-5 4-Methyl-3-nitroanisole 

Downstream Products

• 13324-13-5 4-methoxy-2-nitro-benzoic acid ethyl ester 
• 50424-96-9 4-methoxy-2-nitro-benzoyl chloride 
• 4294-95-5 4-methoxyanthranilic acid 
• 22996-23-2 (4-methoxy-2-nitro-phenyl)-methanol 
• 851847-23-9 N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-4-methoxy-2-nitrobenzamide 
• 74230-08-3 4-hydroxy-2-nitrobenzoic acid 
• 181871-73-8 methyl 4-methoxy-2-nitrobenzoate 
• 1196981-38-0 3-(4'-methoxy-2'-nitrophenyl)-N-pivaloylindole 
• 1224442-40-3 N-[imino(3-methylphenyl)methyl]-4-methoxy-2-nitrobenzamide 
• 1224442-37-8 N-[imino(4-methylphenyl)methyl]-4-methoxy-2-nitrobenzamide 
• 1224442-43-6 C₁₀H₁₁N₃O₄ 
• 1224442-31-2 N-[imino(phenyl)methyl]-4-methoxy-2-nitrobenzamide 
• 1224442-34-5 N-[imino(4-methoxyphenyl)methyl]-4-methoxy-2-nitrobenzamide 
• 99459-34-4 (E)-4-methoxy-2-nitro-β-nitrostyrene 

Relevant academic research and scientific papers

A preparation method for 4-methoxy-2-nitrobenzoic acid

An industrial preparation method for 4-methoxy-2-nitrobenzoic acid is disclosed. In the method, p-difluorobenzene is adopted as an initial raw material and subjected to nitration, ammonolysis, diazotization bromination, cyaniding, methoxylation and hydrolysis which are six steps to synthesize the 4-methoxy-2-nitrobenzoic acid. The 4-methoxy-2-nitrobenzoic acid obtained by the method is white powdered solid with purity being 98.5%, the raw material conversion ratio in each step is 100%, and the total yield of the whole process is 35.8%.

Metal-Free Aerobic Oxidation of Nitro-Substituted Alkylarenes to Carboxylic Acids or Benzyl Alcohols Promoted by NaOH

Efficient and selective aerobic oxidation of nitro-substituted alkylarenes to functional compounds is a fundamental process that remains a challenge. Here, we report a metal-free, efficient, and practical approach for the direct and selective aerobic oxidation of nitro-substituted alkylarenes to carboxylic acids or benzyl alcohols. This sustainable system uses O2 as clean oxidant in a cheap and green NaOH/EtOH mixture. The position and type of substituent critically affect the products. In addition, this sustainable protocol enabled gram-scale preparation of carboxylic acid and benzyl alcohol derivatives with high chemoselectivities. Finally, the reactions can be conducted in a pressure reactor, which can conserve oxygen and prevent solvent loss. The approach was conducive to environmental protection and potential industrial application.

Effect of aldehyde and methoxy substituents on nucleophilic aromatic substitution by [18F]fluoride

For a series of benzaldehydes only with a leaving group or with both a leaving group and a single methoxy substituent 18F-fluorination via nucleophilic aromatic substitution (SNAr) was studied in DMF and Me2SO. In general, the radiochemical yields were clearly higher in DMF than in Me2SO. In the fluorodehalogenation reaction (leaving group: halogen = Br, Cl), extremely low radiochemical yields were observed in Me2SO (2SO (within 3 min reaction time, 90% of the precursor was consumed; radiochemical yield = 1.0 ± 0.5%); however, in DMF oxidation was always kept at a low level during the entire reaction (13C-NMR ppm values of the aromatic carbon atom bearing the leaving group.

HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS

This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

Pyridazinedione compounds useful in treating neurological disorders

The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.

Herbicidally active enols

Enols, their geometric isomers, tautomers and halogen addition products having the formula STR1 as defined herein and compositions containing these compounds exhibit herbicidal activity.

1,2,3-Benzotriazin-4-ones and related systems. Part II. Thermolytic decomposition of substituted 1,2,3-benzotriazin-4-ones and isatoic anhydrides

Several nuclear-substituted 1,2,3-benzotriazin-4-ones have been thermolysed in an inert solvent. In each case the major identifiable product proved to be a 2-(o-aminophenyl)-3,1-benzoxazin-4-one. Nuclear-substituted isatoic anhydrides on thermolysis behaved similarly.