33844-21-2

Basic information

• Product Name: 4-Methoxy-2-nitrobenzoic acid
• Synonyms: 4-METHOXY-2-NITROBENZOIC ACID;2-NITRO-4-METHOXYBENZOIC ACID;RARECHEM AL BO 1421;4-METHOXY-2-NITROBENZOIC ACID 98%;4-Carboxy-3-nitroanisole, 2-Nitro-p-anisic acid
• CAS NO: 33844-21-2
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.14
• Product Categories: blocks;Carboxes;NitroCompounds;Benzoic acid;C8;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 33844-21-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 196.5-200.5 °C(lit.)
• Boiling Point: 372.9 °C at 760 mmHg
• Flash Point: 179.3 °C
• Appearance: /
• Density: 1.43 g/cm³
• Vapor Pressure: 3.2E-06mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Keep Cold
• Solubility: soluble in Methanol
• PKA: 2.46±0.25(Predicted)
• CAS DataBase Reference: 4-Methoxy-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-2-nitrobenzoic acid(33844-21-2)
• EPA Substance Registry System: 4-Methoxy-2-nitrobenzoic acid(33844-21-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 2
• Hazardous Substances Data: 33844-21-2(Hazardous Substances Data)

Usage

General Description

4-Methoxy-2-nitrobenzoic acid, also known as 4-methoxy-2-nitrobenzoic acid, is a compound with the molecular formula C8H7NO5. It is a yellow solid that is commonly used in organic synthesis and pharmaceutical research. This chemical is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also utilized in the production of optical brightening agents and UV stabilizers. Additionally, 4-Methoxy-2-nitrobenzoic acid has potential applications in the development of new materials and is a valuable intermediate in chemical manufacturing processes. However, it is important to handle this compound with care due to its potential hazardous properties.

InChI:InChI=1/C8H7NO5/c1-14-5-2-3-6(8(10)11)7(4-5)9(12)13/h2-4H,1H3,(H,10,11)

Upstream product

• 38469-83-9 4-methoxy-2-nitro-benzonitrile 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 446-09-3 2-bromo-5-fluoronitrobenzene 
• 364-78-3 2-nitro-4-fluoroaniline 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 181871-73-8 methyl 4-methoxy-2-nitrobenzoate 
• 555-03-3 3-nitroanisole 
• 130017-52-6 5-acetylamino-4-methoxy-2-nitrobenzoic acid 
• 130017-51-5 3-acetamido-4-methoxybenzoic acid 
• 204254-70-6 5-amino-4-methoxy-2-nitro-benzoic acid 
• 101080-02-8 1-(chloromethyl)-4-methoxy-2-nitrobenzene 
• 127-09-3 sodium acetate 
• 17484-36-5 4-Methyl-3-nitroanisole 

Downstream Products

• 851847-23-9 N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-4-methoxy-2-nitrobenzamide 
• 4294-95-5 4-methoxyanthranilic acid 
• 74230-08-3 4-hydroxy-2-nitrobenzoic acid 
• 250683-82-0 N-(5-benzamido-2-chlorophenyl)-4-methoxy-2-nitrobenzamide 
• 555-03-3 3-nitroanisole 
• 75753-19-4 4,4'-dimethoxy-2,2'-dinitrobiphenyl 
• 1253180-95-8 (E)-3-(4-methoxy-2-nitro-phenyl)-acrylic acid isobutyl ester 
• 1393456-16-0 C₁₆H₁₃NO₃S 
• 1422357-80-9 N-[4-(2-hydroxyethyl)phenyl]-4-methoxy-2-nitrobenzamide 
• 1422357-86-5 2-amino-N-[4-(2-hydroxyethyl)phenyl]-4-methoxybenzamide 
• 1422357-92-3 C₂₃H₂₁N₃O₆ 
• 848492-86-4 1-allyl-4-methoxy-2-nitrobenzene 
• 1187028-24-5 4-methoxy-1-(2-methylallyl)-2-nitrobenzene 
• 1620682-59-8 1-((E)-3-(4-methoxy-2-nitrophenyl)prop-1-enyl)benzene 

Relevant articles and documents

A preparation method for 4-methoxy-2-nitrobenzoic acid

An industrial preparation method for 4-methoxy-2-nitrobenzoic acid is disclosed. In the method, p-difluorobenzene is adopted as an initial raw material and subjected to nitration, ammonolysis, diazotization bromination, cyaniding, methoxylation and hydrolysis which are six steps to synthesize the 4-methoxy-2-nitrobenzoic acid. The 4-methoxy-2-nitrobenzoic acid obtained by the method is white powdered solid with purity being 98.5%, the raw material conversion ratio in each step is 100%, and the total yield of the whole process is 35.8%.

Effect of aldehyde and methoxy substituents on nucleophilic aromatic substitution by [18F]fluoride

For a series of benzaldehydes only with a leaving group or with both a leaving group and a single methoxy substituent 18F-fluorination via nucleophilic aromatic substitution (SNAr) was studied in DMF and Me2SO. In general, the radiochemical yields were clearly higher in DMF than in Me2SO. In the fluorodehalogenation reaction (leaving group: halogen = Br, Cl), extremely low radiochemical yields were observed in Me2SO (2SO (within 3 min reaction time, 90% of the precursor was consumed; radiochemical yield = 1.0 ± 0.5%); however, in DMF oxidation was always kept at a low level during the entire reaction (13C-NMR ppm values of the aromatic carbon atom bearing the leaving group.

Pyridazinedione compounds useful in treating neurological disorders

The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.