N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Chemical Name:N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide
CAS No.:204692-17-1
Molecular Formula:C₃₁H₃₄N₄O₅
Molecular Weight:542.635
Hs Code.:

Synonyms:N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Chemical Property of N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

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Technology Process of N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

There total 2 articles about N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 20924-05-4
thymidyl acetic acid

: 204692-16-0
2-(2-(((4-methoxyphenyl)-diphenylmethyl)-amino)-ethylamino)ethanol

: 204692-17-1
N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1080/15257779908043084

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 204692-17-1
N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70.3 percent / dimethylformamide; CH₂Cl₂ / 18 h / 0 - 4 °C

2: 36 percent / TOTU; N,N-diisopropylethylamine / dimethylformamide / 16 h / 20 °C

With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Acylation;
DOI:10.1080/15257779908043084