204692-16-0

Upstream product

• 111-41-1 2-(2-Aminoethylamino)ethanol 
• 14470-28-1 mono-4-methoxytrityl chloride 

Downstream Products

• 204692-17-1 N-(2-hydroxyethyl)-N-(2-{[(4-methoxyphenyl)-diphenylmethyl]-amino}-ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide 
• 383429-78-5 N,N,N-(2-hydroxyethyl),(2-(monomethoxytrityl)aminoethyl) tert-butyl glycinate 

Relevant academic research and scientific papers

Synthesis of a monocharged peptide nucleic acid (PNA) analog and its recognition as substrate by DNA polymerases

The preparation of a novel phosphoramidite monomer based on thyminyl acetic acid coupled to the secondary nitrogen of 2-(2-amino- ethylamino)ethanol is described. This monomer can be used to attach a deoxynucleotide to the carboxy terminus of a PNA oligom

Positively-charged peptide nucleic acid analogs with improved properties

The present invention relates to novel types of peptide nucleic acids (PNAS) with improved properties. In particular, it relates to positively charged PNA units having an ethylene linker between the backbone and the nucleobase, to oligonucleotide analogs comprising these units, to oligomers comprising these units, and to the use of positively charged PNAs as novel delivery agents with therapeutic and diagnostic applications including for antisense therapy.