tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

Base Information

Chemical Name:tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate
CAS No.:1095715-64-2
Molecular Formula:C₂₅H₃₈N₄O₄
Molecular Weight:458.601
Hs Code.:

Synonyms:tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

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Chemical Property of tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

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Technology Process of tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

There total 3 articles about tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₃₄N₂O₅

: 127946-77-4
1-amino-1-cyclopropanecarbonitrile hydrochloride

: 1095715-64-2
tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 64h;

Reference yield:

: 85-42-7,13149-00-3,14166-21-3,31982-85-1,71749-03-6,97233-90-4
trans-1,2-cyclohexanedicarboxylic anhydride

: 1095715-64-2
tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 64 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;

Reference yield:

: 46022-05-3
(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid

: 1095715-64-2
tert-butyl 2-[((1R,2R)-2-{[(1-cyanocyclopropyl)amino]carbonyl}cyclohexyl)carbonyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride / 1 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 64 h / 20 °C

With acetic anhydride; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;