(S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one

Base Information

Chemical Name:(S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one
CAS No.:142596-92-7
Molecular Formula:C₁₇H₂₂ClNO₂
Molecular Weight:307.82
Hs Code.:

Synonyms:(S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one

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Chemical Property of (S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one

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Technology Process of (S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one

There total 3 articles about (S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 142596-91-6
1-((S)-2-Methoxy-5-methoxymethyl-pyrrolidin-1-yl)-3-phenyl-pent-4-en-1-one

: 142596-92-7
(S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one

Guidance literature:: With titanium tetrachloride; In dichloromethane; for 25h; -78 deg C to RT;
DOI:10.1016/S0040-4039(00)79559-1

Reference yield:

: 104-54-1
3-Phenylpropenol

: 142596-92-7
(S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one

Guidance literature:: Multi-step reaction with 3 steps

2: 60 percent / 1N tetraethylammonium tosylate / CH₂Cl₂ / anodic oxidation (constant current 27 mA, carbon anode)

3: 92 percent / TiCl₄ / CH₂Cl₂ / 25 h / -78 deg C to RT

With titanium tetrachloride; tetraethylammonium tosylate; In dichloromethane;
DOI:10.1016/S0040-4039(00)79559-1

Reference yield:

: 142596-90-5
1-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-3-phenyl-pent-4-en-1-one

: 142596-92-7
(S)-8-Chloro-3-methoxymethyl-7-phenyl-octahydro-pyrrolo[1,2-a]azepin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / 1N tetraethylammonium tosylate / CH₂Cl₂ / anodic oxidation (constant current 27 mA, carbon anode)

2: 92 percent / TiCl₄ / CH₂Cl₂ / 25 h / -78 deg C to RT

With titanium tetrachloride; tetraethylammonium tosylate; In dichloromethane;
DOI:10.1016/S0040-4039(00)79559-1