5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide
CAS No.:1373840-56-2
Molecular Formula:C₂₃H₂₂FN₅O
Molecular Weight:403.459
Hs Code.:

Synonyms:5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

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Chemical Property of 5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

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Technology Process of 5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

There total 4 articles about 5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1373845-08-9
5-cyclopropyl-6-(4,5-dibromo-1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

: 1373840-56-2
5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; at 20 ℃; for 16h;

Reference yield:

: 1373845-06-7
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole-3-carboxamide

: 1373840-56-2
5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

2: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 16 h / 20 °C

With hydrogen; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; methanol; water; ethyl acetate; 1: Suzuki Coupling;

Reference yield:

: 1373839-73-6
5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide

: 1373840-56-2
5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

3: hydrogen / palladium on activated charcoal / ethyl acetate; methanol / 16 h / 20 °C

With hydrogen; potassium acetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; ethyl acetate; 1: Suzuki Coupling / 2: Suzuki Coupling;