5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide

Base Information

• Chemical Name: 5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide
• CAS No.: 1373839-73-6
• Molecular Formula: C₁₈H₁₅FIN₃O
• Molecular Weight: 435.24
• Mol file: 1373839-73-6.mol

Synonyms:5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide

Chemical Property of 5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide

There total 1 articles about 5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide (1373845-50-1) → 5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide (1373839-73-6)

Guidance literature:

6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide; With hydrogenchloride; sodium nitrite; In water; at -10 - -5 ℃; for 0.5h;

With potassium iodide; In water; ethyl acetate; at 0 ℃; for 1.5h;

Reference yield: 48.0%

5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide (1373839-73-6) + bis(pinacol)diborane (73183-34-3) → 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole-3-carboxamide (1373845-06-7)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dimethyl sulfoxide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield: 24.0%

3,5-dimethylisoxazole-4-boronic acid (16114-47-9) + 5-cyclopropyl-2-(4-fluorophenyl)-6-iodo-N-methyl-2H-indazole-3-carboxamide (1373839-73-6) → 5-cyclopropyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide (1373840-54-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

upstream raw materials:

6-amino-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

Downstream raw materials:

5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole-3-carboxamide

5-cyclopropyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

5-cyclopropyl-6-(4,5-dibromo-1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide

5-cyclopropyl-6-(1-ethyl-1H-imidazol-2-yl)-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide