(Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole

Base Information

Chemical Name:(Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole
CAS No.:245115-89-3
Molecular Formula:C₂₂H₃₁NOS₂Si
Molecular Weight:417.712
Hs Code.:

Synonyms:(Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole

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Chemical Property of (Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole

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Technology Process of (Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole

There total 4 articles about (Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 96685-53-9
(2Z)-2-<(5S)-5-(tert-butyldimethylsilyloxy)-2-methylene-cyclohexylidene>-ethanol

: 149-30-4,118090-09-8
2-Mercaptobenzothiazole

: 245115-89-3
(Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1055/s-1999-3530

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 245115-89-3
(Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / imidazole; DMAP / CH₂Cl₂ / 20 °C

2.1: pyridine; Pb(OAc)4 / CH₂Cl₂ / 0.25 h / 0 °C

2.2: 81 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.25 h / 0 °C

3.1: 89 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C

With pyridine; 1H-imidazole; lead(IV) acetate; dmap; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.1: Etherification / 2.1: Oxidation / 2.2: Reduction / 3.1: Mitsunobu reaction;
DOI:10.1055/s-1999-3530

Reference yield:

: 84985-78-4
(4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol

: 245115-89-3
(Z,S)-2-[2-[5-(tert-Butyldimethylsilyloxy)-2-methylenecyclohexylidene]ethylsulfanyl]benzothiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / imidazole; DMAP / CH₂Cl₂ / 20 °C

2.1: pyridine; Pb(OAc)4 / CH₂Cl₂ / 0.25 h / 0 °C

2.2: 81 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.25 h / 0 °C

3.1: 89 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C

With pyridine; 1H-imidazole; lead(IV) acetate; dmap; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.1: Etherification / 2.1: Oxidation / 2.2: Reduction / 3.1: Mitsunobu reaction;
DOI:10.1055/s-1999-3530