8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Base Information

Chemical Name:8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CAS No.:1841-17-4
Molecular Formula:C₂₉H₂₉F₂N₃O
Molecular Weight:473.566
Hs Code.:

Synonyms:8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

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Chemical Property of 8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

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Technology Process of 8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

There total 8 articles about 8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 817642-33-4
8-[4,4-bis(p-fluorophenyl)-4-hydroxybutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

: 1841-17-4
8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: With hydrogenchloride; In ethanol; for 4h; Heating;
DOI:10.1016/j.tet.2004.09.058

Reference yield:

: 59455-11-7
1-[4-bromo-1-(4-fluorophenyl)but-1-en-1-yl]-4-fluorobenzene

: 1021-25-6
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

: 1841-17-4
8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: With sodium carbonate; potassium iodide; In acetonitrile; at 20 ℃; for 21h; Reflux; Inert atmosphere;
DOI:10.1021/acschemneuro.1c00099

Reference yield:

: 99734-06-2
α,α-bis(4-fluorophenyl)allyl alcohol

: 1841-17-4
8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / [Rh(cod)Cl]2 / dioxane / 65 h / 120 °C / 37503 Torr

2: 100 percent / HCl / ethanol / 4 h / Heating

With hydrogenchloride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In 1,4-dioxane; ethanol;
DOI:10.1016/j.tet.2004.09.058