(E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one
CAS No.:1594133-60-4
Molecular Formula:C₂₈H₂₅ClN₂O₃
Molecular Weight:472.971
Hs Code.:

Synonyms:(E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one

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Chemical Property of (E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one

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Technology Process of (E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one

There total 5 articles about (E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: C₁₇H₁₂ClNO₂

: 73096-98-7
3-dimethylaminomethyl-4-hydroxyacetophenone

: 1594133-60-4
(E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one

Guidance literature:: With sulfuric acid; acetic acid; at 60 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.03.065

Reference yield:

: 15644-86-7
6-chloro-2-methyl-quinolin-4-ol

: 1594133-60-4
(E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus tribromide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 16 h / 70 °C

3: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C

4: acetic acid; sulfuric acid / 2 h / 60 °C

With selenium(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; phosphorus tribromide; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.065

Reference yield:

: C₁₀H₇BrClN

: 1594133-60-4
(E)-3-(6-chloro-4-(4-methoxyphenyl) quinolin-2-yl)-1-(3-((dimethylamino) methyl)-4-hydroxy phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 16 h / 70 °C

2: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C

3: acetic acid; sulfuric acid / 2 h / 60 °C

With selenium(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.03.065