sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate

Base Information

• Chemical Name: sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate
• CAS No.: 1003599-69-6
• Molecular Formula: C₁₂H₁₆NO₅S*Na
• Molecular Weight: 309.319
• Mol file: 1003599-69-6.mol

Synonyms:sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate

Chemical Property of sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate

There total 3 articles about sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(benzyloxy)-N-(3-iodopropyl)acetamide (1003599-67-4) → sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate (1003599-69-6)

Guidance literature:

With sodium sulfite; In methanol; water; for 18h; Heating;

DOI:10.1055/s-2007-990811

Reference yield:

3--1-propyl bromide (94136-47-7) → sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate (1003599-69-6)

Guidance literature:

With sodium sulfite; In water; at 120 ℃;

DOI:10.1016/j.bmcl.2011.07.005

Reference yield:

N-benzyloxyacetamide (4797-81-3) → sodium 3-[acetyl(benzyloxy)amino]propane-1-sulfonate (1003599-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 50 °C

2: sodium sulfite / water / 120 °C

With sodium hydride; sodium sulfite; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.07.005

upstream raw materials:

N-(benzyloxy)-N-(3-iodopropyl)acetamide

N-benzyloxyacetamide

3--1-propyl bromide

Downstream raw materials:

3-[acetyl(benzyloxy)amino]propane-1-sulfonyl chloride

Refernces

• 1、 Perruchon, Johann,Ortmann, Regina,Schlitzer, Martin. "A novel short and efficient synthetic route to the antimalarial agent FR900098 and derivatives". . p. 3553 - 3557. Retrieved 2008/09/19.