94136-47-7Relevant academic research and scientific papers
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis
Andaloussi, Mounir,Lindh, Martin,Bj?rkelid, Christofer,Suresh, Surisetti,Wieckowska, Anna,Iyer, Harini,Karlén, Anders,Larhed, Mats
scheme or table, p. 5403 - 5407 (2011/10/12)
Two series of FR900098/fosmidomycin analogs were synthesized and evaluated for MtDXR inhibition and Mycobacterium tuberculosis whole-cell activity. The design rationale of these compounds involved the exchange of either the phosphonic acid or the hydroxamic acid part for alternative acidic and metal-coordinating functionalities. The best inhibitors provided IC50 values in the micromolar range, with a best value of 41 μM.
Artificial siderophores. 2. Syntheses of trihydroxamate analogues of rhodotorulic acid and their biological iron transport capabilities in Escherichia coli
Lee,Miller,Prody,Neilands
, p. 323 - 327 (2007/10/02)
Tris[(acetylhydroxyamino)alkyl] isocyanurates 2a-c were synthesized from α,ω-dibromoalkanes in four steps. The alkylation of the bromides with O-benzyl-N-[(trichloroethoxy)carbonyl]hydroxylamine in the presence of DBU gave N-alkylation products 7a-c. The
