(1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane

Base Information

Chemical Name:(1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane
CAS No.:910252-42-5
Molecular Formula:C₁₆H₁₈BrN
Molecular Weight:304.23
Hs Code.:

(1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0<sup>4,8</sup>]decane

Synonyms:(1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane

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Chemical Property of (1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane

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Technology Process of (1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane

There total 5 articles about (1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910252-41-4
(1S,3S,4S,8R)-3-(4-Bromo-phenyl)-7-aza-tricyclo[5.3.0.0^4,8]decan-5-one

: 1779-49-3
Methyltriphenylphosphonium bromide

: 910252-42-5
(1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at 37 ℃;
DOI:10.1016/j.bmcl.2006.05.098

Reference yield:

: 910252-40-3
(1R,2S,3S,5S)-3-(4-Bromo-phenyl)-8-ethoxycarbonylmethyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

: 910252-42-5
(1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / toluene / 130 °C

1.2: aq. AcOH; HCl / Heating

2.1: nBuLi / tetrahydrofuran / 37 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; toluene; 1.1: Dieckmann condensation / 2.1: Wittig reactiom;
DOI:10.1016/j.bmcl.2006.05.098

Reference yield:

: 135367-08-7
RTI 51

: 910252-42-5
(1S,3S,4R,8R)-3-(4-Bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0^4,8]decane

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / Heating

2.1: Zn; aq. AcOH / 20 °C

3.1: K₂CO₃ / ethanol / 20 °C

4.1: NaH / toluene / 130 °C

4.2: aq. AcOH; HCl / Heating

5.1: nBuLi / tetrahydrofuran / 37 °C

With n-butyllithium; sodium hydride; potassium carbonate; acetic acid; zinc; In tetrahydrofuran; ethanol; toluene; 4.1: Dieckmann condensation / 5.1: Wittig reactiom;
DOI:10.1016/j.bmcl.2006.05.098