Technology Process of (2R,3S,4S)-N-benzyl-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine
There total 7 articles about (2R,3S,4S)-N-benzyl-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,3S,4R)-4-(benzylamino)-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3-triol;
With
dmap; methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
With
hydrogenchloride;
In
methanol;
at 20 ℃;
for 4h;
Further stages.;
DOI:10.1002/ejoc.200300091
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 86 percent / anhydrous magnesium sulfate / CH2Cl2 / 4 h / 20 °C
2.1: Et2AlCl / tetrahydrofuran / 6 h / -20 °C
3.1: 82 percent / Zn; copper(II) acetate / acetic acid / 1 h / 70 °C
4.1: 100 percent / sodium / diethyl ether; liquid ammonia / 0.25 h / -50 °C
5.1: mesyl chloride; DMAP; triethyl amine / CH2Cl2 / 0 - 20 °C
5.2: 330 mg / HCl / methanol / 4 h / 20 °C
With
dmap; copper diacetate; sodium; diethylaluminium chloride; magnesium sulfate; methanesulfonyl chloride; triethylamine; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane; ammonia; acetic acid;
DOI:10.1002/ejoc.200300091
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Et2AlCl / tetrahydrofuran / 6 h / -20 °C
2.1: 82 percent / Zn; copper(II) acetate / acetic acid / 1 h / 70 °C
3.1: 100 percent / sodium / diethyl ether; liquid ammonia / 0.25 h / -50 °C
4.1: mesyl chloride; DMAP; triethyl amine / CH2Cl2 / 0 - 20 °C
4.2: 330 mg / HCl / methanol / 4 h / 20 °C
With
dmap; copper diacetate; sodium; diethylaluminium chloride; methanesulfonyl chloride; triethylamine; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane; ammonia; acetic acid;
DOI:10.1002/ejoc.200300091
