1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

Base Information

Chemical Name:1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid
CAS No.:134202-67-8
Molecular Formula:C₂₁H₁₃F₂N₃O₃S
Molecular Weight:425.415
Hs Code.:

Synonyms:1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

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Chemical Property of 1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

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Technology Process of 1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

There total 4 articles about 1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 134202-65-6
ethyl 7-(p-tolylthio)-6-fluoro-1-(p-fluorophenyl)-4(1H)-oxopyrido<2,3-c>pyridazine-3-carboxylate

: 134202-67-8
1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

Guidance literature:: With sulfuric acid; In ethanol; water; at 100 - 110 ℃;
DOI:10.1248/cpb.38.3359

Reference yield:

: 134202-64-5
ethyl <2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl>-2-<2-(p-fluorophenyl)hydrazono>acetate

: 134202-67-8
1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / acetonitrile / 0.5 h / Heating

2: 93 percent / conc. H₂SO₄ / H₂O; ethanol / 100 - 110 °C

With sulfuric acid; potassium carbonate; In ethanol; water; acetonitrile;
DOI:10.1248/cpb.38.3359

Reference yield:

: 133413-95-3
ethyl <2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl>acetate

: 134202-67-8
1-(p-fluorophenyl)-6-fluoro-4(1H)-oxo-7-(p-tolylthio)pyrido<2,3-c>pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaNO₂, 20percent HCl, 2) NaOAc / 1) H₂O, below 0 deg C, 2a) EtOH, CHCl₃, below 10 deg C, 15 min, b) room temperature, 30 min

2: 97 percent / K₂CO₃ / acetonitrile / 0.5 h / Heating

3: 93 percent / conc. H₂SO₄ / H₂O; ethanol / 100 - 110 °C

With hydrogenchloride; sulfuric acid; sodium acetate; potassium carbonate; sodium nitrite; In ethanol; water; acetonitrile;
DOI:10.1248/cpb.38.3359