76041-72-0

Usage

Uses

Used in Pharmaceutical Industry:
2-MERCAPTO-5-(TRIFLUOROMETHYL)PYRIDINE is used as a reactant for synthesizing anti-tumor agents, playing a vital role in the development of cancer treatments. Its incorporation into these agents aids in targeting and combating tumor growth, offering potential therapeutic benefits for patients suffering from various types of cancer.
Additionally, 2-MERCAPTO-5-(TRIFLUOROMETHYL)PYRIDINE is used as a reactant for synthesizing HIV protease inhibitors. These inhibitors are essential in the fight against HIV and AIDS, as they help to prevent the replication of the virus within the body, thus managing the progression of the disease and improving the quality of life for those affected.

InChI:InChI=1/C6H3BrF3NO/c7-4-1-3(6(8,9)10)2-11-5(4)12/h1-2H,(H,11,12)

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 33252-63-0 2-hydroxy-5-(trifluoromethyl)pyridine 
• 69045-82-5 2-fluoro-5-(trifluoromethyl)pyridine 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 

Downstream Products

• 142274-35-9 (5-trifluoromethylpyridin-2-ylsulphanyl)-acetic acid methyl ester 
• 174485-72-4 5-trifluoromethyl-pyridin-2-ylsulfonylchloride 
• 882985-35-5 4-(5-trifluoromethyl-pyridin-2-ylsulfanyl)-benzaldehyde 
• 913091-80-2 2-bromo-5-[(2,5-difluorophenyl)[[5-(trifluoromethyl)pyridin-2-yl]thio]methyl]-4-methylpyridine 
• 1093058-25-3 (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[{(5-trifluoromethyl)pyridin-2-ylsulfanyl}methyl]-1,3-dioxolane 
• 1219036-57-3 CF₃O₃S^(1-)*C₂₁H₃₁F₃N₃O⁽¹⁺⁾ 
• 1268698-59-4 C₁₄H₆F₃N₃S 
• 119811-95-9 2-(4-methylphenyl)-5-trifluoromethylpyridine 
• 139218-75-0 5-Trifluoromethyl-2-(4-hydroxyphenyl)pyridine 
• 223127-48-8 methyl 4-(5-(trifluoromethyl)pyridin-2-yl)benzoate 

Relevant academic research and scientific papers

Silver-induced self-immolative Cl-F exchange fluorination of arylsulfur chlorotetrafluorides: Synthesis of arylsulfur pentafluorides

A novel strategy for the synthesis of arylsulfur pentafluorides by silver carbonate-induced Cl-F exchange fluorination of arylsulfur chlorotetrafluorides is reported. This fluorination does not require any exogenous fluoride sources. Rather, the reaction proceeds via the self-immolation of the substrate Ar-SF4Cl.

IF5 affects the final stage of the Cl-F exchange fluorination in the synthesis of pentafluoro-λ6-sulfanyl-pyridines, pyrimidines and benzenes with electron-withdrawing substituents

A difficult chlorine-fluorine (Cl-F) exchange fluorination reaction in the final stage of the preparation of pentafluoro-λ6-sulfanyl-(hetero)arenes having electron-withdrawing substituents has now been elucidated through the use of iodine pentafluoride. A major side-reaction of C-S bond cleavage was sufficiently inhibited by the potential interaction between F and I with a halogen bonding.

Synthesis and characterization of 2-pyridylsulfur pentafluorides

Current approaches to prepare SF5-substituted heterocycles during the synthesis of targeted heterocyclic compounds require the use of SF5-functionalized aryl or alkyne reagents or SF5Cl as a source of the SF5 functional group. Herein we report that excess oxidative fluorination of 2,2' -dipyridyl disulfide with a KF/Cl2 /MeCN system leads to the formation of thirteen new 2-pyridylsulfur chlorotetrafluorides (2-SF4Cl-pyridines). These molecules are found to undergo further chlorine-fluorine exchange reactions by treatment with silver(I) fluoride enabling ready access to a series of ten new substituted 2-pyridylsulfur pentafluorides (2-SF5-pyridines). This is the first preparatively simple and readily scalable example of the transformation of an existing heterocyclic sulfur functionality to prepare SF5-substituted heterocycles.

PYRIDYLMETHYLSULFONE DERIVATIVE

Disclosed is a novel compound having an effect of inhibiting the production/secretion of β-amyloid protein. A compound represented by the general formula (1) or a salt or a solvate of the compound or the salt; and a pharmaceutical agent comprising the compound, salt or solvate.

BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a novel benzazepine derivative represented by formula : wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula -W1-X2-W2- (W1 and W2 are independently S(O)m1 (m1 is 0, 1 or 2), etc., and X2 is an optionally substituted alkylene groupetc. ), a preparation method and use thereof.

The Synthesis and Some Reactions of Novel Pyridine-2(1H)-thiones

The use of methyl 3-mercaptopropionate for the conversion of halogenated pyridins to pyridine thiones and thiols is described, and limitations of the reaction discussed.S-Alkylation and oxidation reactions of the products from these reactions are reported.

SOME NEW 2-SUBSTITUTED 5-TRIFLUOROMETHYLPYRIDINES

The preparation of the derivatives of 2-amino-, hydrazino-, hydroxy-, and mercapto-5-trifluoromethylpyridines via 2-chloro precursors is describes.Experimental and spectral data of the products together with those of the precursors are presented.