5-METHYL-2-(TRIFLUOROMETHYL)ANILINE

Base Information

• Chemical Name: 5-METHYL-2-(TRIFLUOROMETHYL)ANILINE
• CAS No.: 106877-29-6
• Molecular Formula: C8H8 F3 N
• Molecular Weight: 175.153
• Hs Code.: 2921430090
• Mol file: 106877-29-6.mol

Synonyms:2-Trifluoromethyl-5-methylaniline

Chemical Property of 5-METHYL-2-(TRIFLUOROMETHYL)ANILINE

Chemical Property:

• Vapor Pressure: 0.228mmHg at 25°C
• Refractive Index: 1.481
• Boiling Point: 207.2°C at 760 mmHg
• Flash Point: 86.1°C
• PSA: 26.02000
• Density: 1.237g/cm³
• LogP: 3.17720
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

5-Methyl-2-(trifluoromethyl)aniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-2-(TRIFLUOROMETHYL)ANILINE

There total 7 articles about 5-METHYL-2-(TRIFLUOROMETHYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methyl-2-nitro-1-(trifluoromethyl)benzene (154057-13-3) → 5-methyl-2-(trifluoromethyl)aniline (106877-29-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 4h; under 760.051 Torr;

Reference yield: 12.0%

Bromotrifluoromethane (75-63-8) + 1-amino-3-methylbenzene (108-44-1) → 3-methyl-4-trifluoromethylphenylamine (106877-31-0) + 5-methyl-2-(trifluoromethyl)aniline (106877-29-6) + 3-methyl-2-trifluoromethylaniline (106877-30-9)

Guidance literature:

With α-picoline; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 20 ℃; for 2h; under 2250.2 - 3750.3 Torr;

Reference yield: 12.0%

→ 5-methyl-2-(trifluoromethyl)aniline (106877-29-6)

Guidance literature:

upstream raw materials:

Bromotrifluoromethane

1-amino-3-methylbenzene

4-methyl-2-nitro-1-(trifluoromethyl)benzene

4-methyl-2-nitrobenzoic acid

Refernces

• 1、 -. "QUINOXALINE DERIVATIVES". Page/Page column 82. . Retrieved 2021/07/24.
• 2、 -. "ALK KINASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF". Paragraph 0133; 0134; 0135. . Retrieved 2017/04/18.