(3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

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Chemical Name:(3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid
CAS No.:1423134-24-0
Molecular Formula:C₃₀H₃₆FN₅O₅
Molecular Weight:565.645
Hs Code.:

Synonyms:(3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

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Chemical Property of (3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

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Technology Process of (3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

There total 10 articles about (3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₄FN₅O₇

: 1423134-24-0
(3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Guidance literature:: With formic acid; at 5 ℃; for 18h;

Reference yield:

: 169498-28-6
(3R)-1-{3-[1-(tert-butoxycarbonyl)-4-piperidinyl]propanoyl}-3-piperidinecarboxylic acid

: 1423134-24-0
(3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexyl-carbodiimide / 1,2-dimethoxyethane / 4 h / 20 °C

2: triethylamine / dichloromethane; N,N-dimethyl-formamide / 22 h / 0 - 60 °C

3: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h

4: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

5: barium hydroxide octahydrate / methanol; tert-butyl alcohol / 0.75 h / 20 °C

6: formic acid / 18 h / 5 °C

With formic acid; barium hydroxide octahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1423134-79-5
tert-butyl {[5-(benzyloxy)pyridin-3-yl](phenylsulfonyl)methyl}carbamate

: 1423134-24-0
(3S)-3-{5-[(4-cyano-3-fluorobenzyl)oxy]pyridin-3-yl}-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea / water; toluene / 120 h / 0 - 5 °C

2: hydrogenchloride / 1,4-dioxane / 20 h

3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 22 h / 0 - 60 °C

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h

5: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

6: barium hydroxide octahydrate / methanol; tert-butyl alcohol / 0.75 h / 20 °C

7: formic acid / 18 h / 5 °C

With hydrogenchloride; formic acid; barium hydroxide octahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; triethylamine; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;