1-(3-bromophenyl)cyclohexanecarbonitrile

Base Information

• Chemical Name: 1-(3-bromophenyl)cyclohexanecarbonitrile
• CAS No.: 676138-32-2
• Molecular Formula: C₁₃H₁₄BrN
• Molecular Weight: 264.165
• Mol file: 676138-32-2.mol

Synonyms:1-(3-bromophenyl)cyclohexanecarbonitrile

Chemical Property of 1-(3-bromophenyl)cyclohexanecarbonitrile

Chemical Property:

Purity/Quality:

1-(3-Bromophenyl)cyclohexanecarbonitrile 95% ^*data from reagent suppliers

Safty Information:

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Technology Process of 1-(3-bromophenyl)cyclohexanecarbonitrile

There total 2 articles about 1-(3-bromophenyl)cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,5-dibromo-pentane (111-24-0) + 3-cyanobromobenzene (6952-59-6) → 1-(3-bromophenyl)cyclohexanecarbonitrile (676138-32-2)

Guidance literature:

3-cyanobromobenzene; With potassium tert-butylate; In tetrahydrofuran; at 0 - 9 ℃; for 1.25h;

1,5-dibromo-pentane; In tetrahydrofuran; at 15 - 20 ℃; for 3h;

Reference yield: 58.0%

1,5-dibromo-pentane (111-24-0) + (3-bromophenyl)acetonitrile (31938-07-5) → 1-(3-bromophenyl)cyclohexanecarbonitrile (676138-32-2)

Guidance literature:

(3-bromophenyl)acetonitrile; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.833333h;

1,5-dibromo-pentane; In dimethyl sulfoxide; mineral oil; at 0 - 20 ℃; for 1h;

DOI:10.1021/acsmedchemlett.9b00134

Reference yield: 74.0%

1-(3-bromophenyl)cyclohexanecarbonitrile (676138-32-2) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine (1160502-13-5) → C38H32N4

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.9b00134

upstream raw materials:

1,5-dibromo-pentane

3-cyanobromobenzene

(3-bromophenyl)acetonitrile

Downstream raw materials:

1-(3-bromophenyl)cyclohexanecarboxamide

1-(3'-methyl-[1,1'-biphenyl]-3-yl)cyclohexanecarboxylic acid

5-(m-tolyl)-2H-spiro[benzofuran-3,1'-cyclohexan]-2-one

(1-(3-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)cyclohexyl)methanamine

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