4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Base Information

Chemical Name:4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine
CAS No.:1160502-13-5
Molecular Formula:C₃₁H₃₀BN₃O₂
Molecular Weight:487.409
Hs Code.:

Synonyms:4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

Boiling Point:646.3±55.0 °C(Predicted)
Density:1.13±0.1 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

There total 4 articles about 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1160502-12-4
4-iodo-1-trityl-1H-pyrazolo[3,4-b]pyridine

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1160502-13-5
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 120 ℃; for 24h; Inert atmosphere;

Reference yield: 74.0%

: 1160502-12-4
4-iodo-1-trityl-1H-pyrazolo[3,4-b]pyridine

: 73183-34-3
bis(pinacol)diborane

: 1160502-13-5
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 120 ℃; for 24h; Product distribution / selectivity;

Reference yield:

: 861881-02-9
4-iodo-1H-pyrazolo[3,4-b]pyridine

: 1160502-13-5
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h

1.2: 2.5 h / 0 - 20 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere; Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.9b00134