Technology Process of 2-(4-acetaminophenyl)-1,8a-dihydroazulene-1,1-dicarbonitrile
There total 4 articles about 2-(4-acetaminophenyl)-1,8a-dihydroazulene-1,1-dicarbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[2-(cyclohepta-2,4,6-trienyl)-1-(4-acetaminophenyl)ethylidene]malononitrile;
With
trityl tetrafluoroborate;
In
1,2-dichloro-ethane;
for 1h;
Inert atmosphere;
Reflux;
With
triethylamine;
In
1,2-dichloro-ethane;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo4020326
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; ammonium acetate / toluene / 3 h / Dean-Stark; Reflux
2.1: water; 1,4-dioxane / 0.5 h / 70 °C / Inert atmosphere; Heating
3.1: triethylamine / dichloromethane / 5 h / -78 °C / Inert atmosphere
4.1: trityl tetrafluoroborate / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux
4.2: 4 h / 0 - 20 °C / Inert atmosphere
With
ammonium acetate; trityl tetrafluoroborate; acetic acid; triethylamine;
In
1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; toluene;
1.1: |Knoevenagel Condensation;
DOI:10.1021/jo4020326
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 5 h / -78 °C / Inert atmosphere
2.1: trityl tetrafluoroborate / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux
2.2: 4 h / 0 - 20 °C / Inert atmosphere
With
trityl tetrafluoroborate; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo4020326
![2-[2-(cyclohepta-2,4,6-trienyl)-1-(4-acetaminophenyl)ethylidene]malononitrile](/Databaselist/images/loading.webp)
