(-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate

Base Information

Chemical Name:(-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate
CAS No.:1312025-90-3
Molecular Formula:C₂₆H₃₈N₂O₄S
Molecular Weight:474.665
Hs Code.:

Synonyms:(-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate

Suppliers and Price of (-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate

There total 2 articles about (-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1071508-52-5
(+)-(S)-O-cyclohexyl(tri-n-butylstannyl)methyl pyrrolidine-1-carbothioate

: 1279668-23-3
(-)-(S)-S-4-nitrophenyl 2-(tert-butoxycarbonyl)amino-3-phenylpropanethioate

: 1312025-90-3
(-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate

Guidance literature:: With copper(I) thiophene-2-carboxylate; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere;
DOI:10.1021/ol201330j

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1312025-90-3
(-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24.25 h / 0 - 20 °C

2: copper(I) thiophene-2-carboxylate / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With copper(I) thiophene-2-carboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ol201330j