1071508-52-5

Upstream product

• 123-75-1 pyrrolidine 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 1312026-01-9 (-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-4-(1H-indol-3-yl)-2-oxobutyl pyrrolidine-1-carbothioate 
• 1312025-98-1 (-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-6-cyclohexyl-5-oxo-6-[(pyrrolidine-1-carbonothioyl)oxy]hexanoate 
• 1312025-93-6 (-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxobutyl pyrrolidine-1-carbothioate 
• 1312025-90-3 (-)-O-(1R,3S)-3-(tert-butoxycarbonyl)amino-1-cyclohexyl-2-oxo-4-phenylbutyl pyrrolidine-1-carbothioate 

Relevant academic research and scientific papers

Synthesis of enantioenriched α-(hydroxyalkyl)-tri-n-butylstannanes

(Chemical Equation Presented) Li and Mg are pesky: A catalytic asymmetric synthesis of α-(hydroxyalkyl)-tri-n-butylstannanes (1) in good to excellent yields and enantioselectivities was achieved (see scheme; PG=protecting group; L=chiral ligand). Compound 1 was isolated as an ester or thiocarbamate, and the reagent was prepared from equimolar amounts of nBu3SnH and Et2Zn in dimethoxyethane. Conditions employing lithium or magnesium ions suppress enantioselectivity.