ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate
CAS No.:138733-08-1
Molecular Formula:C₂₅H₂₅F₃N₆O₂
Molecular Weight:498.508
Hs Code.:

Synonyms:ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

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Chemical Property of ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

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Technology Process of ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

There total 12 articles about ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 138733-08-1
ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / N,N-diisopropylethylamine, LiBr / tetrahydrofuran / 15 h / Heating

2: 29 percent / ethanol / 4 h / Heating

3: BBr₃ / CH₂Cl₂ / 13 h / 0 - 20 °C

4: Na₂CO₃, H₂O / dioxane / 3 h / Heating

5: Na₂Cr₂O₇, H₂O, H₂SO₄ / 5 h / 35 °C

6: DCC, DMAP / CHCl₃ / 2 h / Ambient temperature

7: 1.) Me₃SnN₃, 2.) gas. HCl / 1.) xylene, reflux, 30 h, 2.) THF, 10 min

With hydrogenchloride; dmap; sodium dichromate; sulfuric acid; water; boron tribromide; azidotrimethyltin; sodium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium bromide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform;
DOI:10.1248/cpb.42.1617

Reference yield:

: 36983-31-0
ethyl 3-butyrylpyruvate

: 138733-08-1
ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 723 mg / ethanol / 22 h / Ambient temperature

2: 63 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

3: 40 percent / conc. HCl / acetic acid; 2-methoxy-ethanol / 24 h / 105 °C

4: 1.) trimethyltin azide, 2.) silica gel / 1.) toluene, reflux, 54 h, 2.) MeOH, RT, 2 h

With hydrogenchloride; trimethyltin azide; silica gel; potassium carbonate; In ethanol; 2-methoxy-ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00075a014

Reference yield:

: 152713-53-6
ethyl 2-(methoxyimino)-4-oxoheptanoate

: 138733-08-1
ethyl 3-n-propyl-4-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

2: 40 percent / conc. HCl / acetic acid; 2-methoxy-ethanol / 24 h / 105 °C

3: 1.) trimethyltin azide, 2.) silica gel / 1.) toluene, reflux, 54 h, 2.) MeOH, RT, 2 h

With hydrogenchloride; trimethyltin azide; silica gel; potassium carbonate; In 2-methoxy-ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00075a014