3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride

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Chemical Name:3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride
CAS No.:1228102-09-7
Molecular Formula:C₂₃H₂₂N₄OS*ClH
Molecular Weight:438.981
Hs Code.:

Synonyms:3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride

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Chemical Property of 3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride

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Technology Process of 3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride

There total 4 articles about 3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1228102-98-4
N-(3-(tert-butyldimethylsiloxy)phenyl)-6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine

: 1228102-09-7
3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 87199-17-5
4-formylphenylboronic acid,

: 1228102-09-7
3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 3 h / Reflux

2.1: 1,2-dichloro-ethane / 0.33 h

2.2: 7 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 15 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; 1.1: |Suzuki Coupling;

Reference yield:

: 1228102-69-9
4-(4-(3-(t-butyldimethylsiloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)benzaldehyde

: 1228102-09-7
3-(6-(4-(pyrrolidin-1-ylmethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 0.33 h

1.2: 7 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 15 h / 20 °C

With hydrogenchloride; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;