diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate

Base Information

Chemical Name:diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate
CAS No.:1050239-39-8
Molecular Formula:C₁₈H₁₇F₄NO₅
Molecular Weight:403.33
Hs Code.:

Synonyms:diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate

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Technology Process of diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate

There total 2 articles about diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005336-33-3
4-(chloromethyl)-2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazole

: 1050239-39-8
diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate

Guidance literature:: With sodium iodide; In water; N,N-dimethyl-formamide; diethyl malonate; mineral oil;

Reference yield:

: 1005336-33-3
4-(chloromethyl)-2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazole

: 105-53-3
diethyl malonate

: 1050239-39-8
diethyl 2-({2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl}methyl)propane-1,3-dioate

Guidance literature:: diethyl malonate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.666667h;

4-(chloromethyl)-2-[5-fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazole; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

With sodium iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;