2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid

Base Information

• Chemical Name: 2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid
• CAS No.: 885024-39-5
• Molecular Formula: C₂₄H₂₁F₃N₄O₅
• Molecular Weight: 502.45
• Mol file: 885024-39-5.mol

Synonyms:2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid

Chemical Property of 2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid

There total 1 articles about 2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-methoxy-2-(7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl)-benzoic acid bis-potassium salt + 4-iodo-N,N-dimethylbenzamide (24167-53-1) → 2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid (885024-39-5)

Guidance literature:

With tetrakis(acetonitrile)copper(I) hexafluorophosphate; In dimethyl sulfoxide; at 150 ℃; for 1h; Microwave;

Reference yield:

2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid (885024-39-5) + N-benzyl-2-aminoacetamide (39796-52-6) → C24H22F3N5O4 (885022-88-8)

Guidance literature:

2-[6-(4-dimethylcarbamoyl-phenyl)-7-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[3,4-c]pyridin-1-yl]-5-methoxybenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.25h;

N-benzyl-2-aminoacetamide; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃; for 12h;

upstream raw materials:

4-iodo-N,N-dimethylbenzamide

Downstream raw materials:

C₂₄H₂₂F₃N₅O₄