24167-53-1

Basic information

• Product Name: 4-Iodo-N,N-dimethylbenzamide
• Synonyms: 4-Iodo-N,N-dimethylbenzamide;N,N-Dimethylcarbamoyl-4-iodobenzene;p-Iodo-N,N-dimethylbenzamide
• CAS NO: 24167-53-1
• Molecular Formula: C₉H₁₀INO
• Molecular Weight: 275.08627
• Mol File: 24167-53-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 339℃
• Flash Point: 159℃
• Appearance: /
• Density: 1.649
• Vapor Pressure: 9.54E-05mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• PKA: -1.36±0.70(Predicted)
• CAS DataBase Reference: 4-Iodo-N,N-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodo-N,N-dimethylbenzamide(24167-53-1)
• EPA Substance Registry System: 4-Iodo-N,N-dimethylbenzamide(24167-53-1)

Safety Data

• Hazardous Substances Data: 24167-53-1(Hazardous Substances Data)

Usage

General Description

4-Iodo-N,N-dimethylbenzamide is a chemical compound with the molecular formula C10H12INO and a molecular weight of 279.11 g/mol. It is an iodo-substituted benzamide derivative, which is commonly used as an intermediate in the synthesis of pharmaceutical compounds and research chemicals. This chemical is a white to off-white solid at room temperature, and it is sparingly soluble in water but soluble in organic solvents such as dimethyl sulfoxide and methanol. 4-Iodo-N,N-dimethylbenzamide is primarily used in chemical research and development, particularly in the pharmaceutical industry, although it has potential applications in other fields such as agrochemicals and material science. Additionally, it is important to handle this compound with caution, as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C9H10INO/c1-11(2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 1711-02-0 4-iodobenzoic acid chloride 
• 619-58-9 4-iodobenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 124-40-3 dimethyl amine 
• 51934-41-9 4-iodobenzoic acid ethyl ester 

Downstream Products

• 99847-42-4 (4-chlorophenyl)(4-iodophenyl)methanone 
• 1380167-95-2 N,N-dimethyl-4-(phenylethynyl)benzamide 
• 130447-23-3 n-butyl 4-iodobenzoate 
• 1358929-60-8 (+/-)-1-(4-iodophenyl)-N,N-dimethyl-2-phenylethanamine 

Relevant articles and documents

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

HOMOBISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain substituted bispiperidinyl compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein ring A, ring B, R1, R2, R3, L, R4, X, Z, Li, Q and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver Χ-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

Copper-catalyzed amide bond formation from formamides and carboxylic acids

A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv. formamides.