24167-53-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Iodo-N,N-dimethylbenzamide is employed as an intermediate in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for its use in creating a range of medicinally relevant molecules.
Used in Chemical Research and Development:
In the realm of chemical research and development, 4-Iodo-N,N-dimethylbenzamide serves as a valuable compound for studying the properties and reactions of iodo-substituted benzamides. This aids in advancing the understanding of chemical behavior and the creation of novel chemical entities.
Used in Agrochemicals:
Although not extensively detailed in the provided materials, 4-Iodo-N,N-dimethylbenzamide has potential applications in the agrochemical industry, possibly serving as a precursor or component in the development of pesticides or other agricultural chemicals.
Used in Material Science:
Similarly, the compound may also find use in material science, potentially contributing to the development of new materials with specific properties, such as those with altered electronic or optical characteristics.
It is crucial to handle 4-Iodo-N,N-dimethylbenzamide with care due to its potential health and environmental risks if mismanaged. Proper safety measures should be implemented during its use to mitigate any associated risks.

InChI:InChI=1/C9H10INO/c1-11(2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 619-58-9 4-iodobenzoic acid 
• 1711-02-0 4-iodobenzoic acid chloride 

Downstream Products

• 851895-22-2 N,N-dimethyl-4-((trimethylsilyl)ethynyl) benzamide 
• 1380167-95-2 N,N-dimethyl-4-(phenylethynyl)benzamide 
• 99847-42-4 (4-chlorophenyl)(4-iodophenyl)methanone 

Relevant academic research and scientific papers

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

Heme Protein Catalysts for Carbon-Silicon Bond Formation In Vitro and In Vivo

The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.

HOMOBISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain substituted bispiperidinyl compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein ring A, ring B, R1, R2, R3, L, R4, X, Z, Li, Q and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver Χ-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes

An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol.

Copper-catalyzed amide bond formation from formamides and carboxylic acids

A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv. formamides.

Copper-catalyzed oxidative coupling of carboxylic acids with N,N-dialkylformamides: An approach to the synthesis of amides

A new synthetic approach for amide bond formation through the oxidative coupling of N,N-dialkylformamides with carboxylic acids was achieved by using a copper catalyst. Furthermore, this method was applied in the coupling of chiral amino acids in which the stereochemistry was retained in the resulting amide products. A new synthetic approach to amide bond formation through the oxidative coupling of N,N-dialkylformamides with carboxylic acids was achieved by using a copper catalyst and aqueous tert-butyl hydroperoxide (TBHP) as a sacrificial oxidant. Furthermore, this method was applied in the coupling of chiral amino acids in which the stereochemistry was retained in the resulting amide products. Copyright

Electrochemical synthesis of amides: Direct transformation of methyl ketones with formamides

A direct transformation from methyl ketones to secondary or tertiary amides has been developed through a novel electrochemical approach and a wide scope of formamides could be utilized as the amide sources. This transformation was promoted by in situ generated iodine through electrolysis of sodium iodide under mild, metal-free conditions. This electrochemical procedure could avoid the use of stoichiometric iodine and afforded the target products in good to excellent yields.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compounds of formula (I) and salts and solvates are provided: formula (I). Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

Benzodioxepine derivatives

This invention relates to compounds of the formula wherein B, X, Y, Z, R1 and R2 are as defined in the description, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by ACCβ inhibitors.

BENZO [b][1,4] DIOXEPINE DERIVATIVES

This invention relates to compounds of the formula (I), wherein B, X, Y, Z, R1 and R2 are as defined in the description, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by ACCβ inhibitors.