(Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate

Base Information

Chemical Name:(Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate
CAS No.:1296665-03-6
Molecular Formula:C₂₁H₂₉NO₆
Molecular Weight:391.464
Hs Code.:

Synonyms:(Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate

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Chemical Property of (Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate

Chemical Property:

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Technology Process of (Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate

There total 4 articles about (Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₅NO₃

: 4755-77-5
Ethyl oxalyl chloride

: 1296665-03-6
(Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c0ob00978d

Reference yield:

: 1296664-99-7
tert-butyl 2-(2-benzyloxyethyl)-3-oxobutanoate

: 1296665-03-6
(Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; ammonia / ethanol / 60 °C / Pressure tube

2: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; ammonium acetate; ammonia; In ethanol; dichloromethane;
DOI:10.1039/c0ob00978d

Reference yield:

: 1694-31-1
tert-butyl acetoacetate

: 1296665-03-6
(Z)-tert-butyl 2-(2-benzyloxyethyl)-3-(2-ethoxy-2-oxoacetamido)-2-butenoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tert-butyl alcohol / 18 h / Inert atmosphere; Reflux

2: ammonium acetate; ammonia / ethanol / 60 °C / Pressure tube

3: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; ammonium acetate; ammonia; caesium carbonate; In ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1039/c0ob00978d