N₄-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine
• CAS No.: 850247-28-8
• Molecular Formula: C₂₂H₂₀N₆O
• Molecular Weight: 384.44

Synonyms:N₄-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine

Chemical Property of N₄-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine

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Technology Process of N₄-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine

There total 1 articles about N₄-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile (850247-06-2) → N4-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine (850247-28-8)

Guidance literature:

4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile; With hydrogen; palladium 10% on activated carbon; In acetic acid; under 2280.15 Torr;

With triethylamine; In DMF (N,N-dimethyl-formamide);

Reference yield: 63.0%

N4-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine (850247-28-8) + N,N-diethylcarbamyl chloride (88-10-8) → N'-[(4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy}pyridin-2-yl)methyl]-N,N-diethylurea

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield: 42.2%

N4-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine (850247-28-8) + acetone (67-64-1) → N4-[4-({2-[(isopropylamino)methyl]pyridin-4-yl}oxy)phenyl]-6-phenylpyrimidine-2,4-diamine

Guidance literature:

N₄-(4-{[2-(aminomethyl)pyridin-4-yl]oxy}phenyl)-6-phenylpyrimidine-2,4-diamine; acetone; With tetramethoxytitanium; In dichloromethane; at 20 ℃; for 24h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy}pyridine-2-carbonitrile

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