5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N₃-methyl-3H-pyrimidin-4-one

Base Information

• Chemical Name: 5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N₃-methyl-3H-pyrimidin-4-one
• CAS No.: 1338091-27-2
• Molecular Formula: C₂₁H₁₇FN₄O₃
• Molecular Weight: 392.389

Synonyms:5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N₃-methyl-3H-pyrimidin-4-one

Chemical Property of 5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N₃-methyl-3H-pyrimidin-4-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N₃-methyl-3H-pyrimidin-4-one

There total 13 articles about 5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N₃-methyl-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-benzyloxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid N'-[2-(4-fluorophenyl)acetyl]hydrazide (1338091-26-1) → 5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N3-methyl-3H-pyrimidin-4-one (1338091-27-2)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In acetonitrile; at 20 ℃; Product distribution / selectivity;

Reference yield:

p-Fluorophenylacetic acid (405-50-5) → 5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N3-methyl-3H-pyrimidin-4-one (1338091-27-2)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 1 h / 80 °C

2: hydrazine hydrate / dichloromethane / 1.5 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: triphenylphosphine; tetrachloromethane / acetonitrile / 20 °C

With tetrachloromethane; thionyl chloride; hydrazine hydrate; triethylamine; triphenylphosphine; In dichloromethane; acetonitrile;

Reference yield:

4-Fluorophenylacetyl chloride (459-04-1) → 5-benzyloxy-6-[5-(4-fluorobenzyl)-[1,3,4]oxadiazol-2-yl]-N3-methyl-3H-pyrimidin-4-one (1338091-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / dichloromethane / 1.5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: triphenylphosphine; tetrachloromethane / acetonitrile / 20 °C

With tetrachloromethane; hydrazine hydrate; triethylamine; triphenylphosphine; In dichloromethane; acetonitrile;

upstream raw materials:

p-Fluorophenylacetic acid

4-Fluorophenylacetyl chloride

ethyl 2-(4-fluorophenyl)acetate

methyl 2-(benzyloxy)acetate

Downstream raw materials:

5-benzyloxy-6-[5-(4-fluorobenzyl)[1,3,4]oxadiazol-2-yl]-3-methyl-3H-pyrimidin-4-one oxime

C₁₄H₁₂FN₅O₃

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