(2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate

Base Information

Chemical Name:(2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate
CAS No.:119595-79-8
Molecular Formula:C₃₁H₃₂N₂O₄
Molecular Weight:496.606
Hs Code.:

Synonyms:(2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate

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Chemical Property of (2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate

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Technology Process of (2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate

There total 5 articles about (2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 119595-73-2
L-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))glutamate

: 590-17-0
cyanomethyl bromide

: (S)-2-Bromo-4-(9-phenyl-9H-fluoren-9-ylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester

: 119595-75-4,119595-79-8
<2S,4(R,S)>-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate

Guidance literature:: With potassium hexamethylsilazane; Product distribution; var. reactants and reaction partners;
DOI:10.1021/jo00269a022

Reference yield:

: 1499-55-4
L-glutamic acid 5-methyl ester

: 119595-79-8
(2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: CHCl₃ / 2 h / Heating

2: lead nitrate, Et₃N / CHCl₃ / 87 h / Ambient temperature

3: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature

4: 1.) lithium 2,2,6,6-tetramethylpiperidide (LiTMP) / 1.) THF, -78 deg C, 30 min, 2.) THF, 2 h

With lead(II) nitrate; 2,2,6,6-tetramethylpiperidinyl-lithium; triethylamine; In dichloromethane; chloroform;
DOI:10.1021/jo00269a022

Reference yield:

: C₉H₁₉NO₄Si

: 119595-79-8
(2S,4R)-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))-4-(cyanomethyl)glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: lead nitrate, Et₃N / CHCl₃ / 87 h / Ambient temperature

2: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature

3: 1.) lithium 2,2,6,6-tetramethylpiperidide (LiTMP) / 1.) THF, -78 deg C, 30 min, 2.) THF, 2 h

With lead(II) nitrate; 2,2,6,6-tetramethylpiperidinyl-lithium; triethylamine; In dichloromethane; chloroform;
DOI:10.1021/jo00269a022