(2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide

Base Information

• Chemical Name: (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide
• CAS No.: 1253798-50-3
• Molecular Formula: C₂₃H₃₁N₃O₉S
• Molecular Weight: 525.58

Synonyms:(2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide

Chemical Property of (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide

There total 4 articles about (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-2-[allyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide (1253798-37-6) → (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide (1253798-50-3)

Guidance literature:

With potassium osmate(VI) dihydrate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 ℃;

DOI:10.1002/cmdc.201000230

Reference yield:

(S)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(2-nitrobenzenesulfonylamino)butyramide (1253798-49-0) → (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide (1253798-50-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 4.5 h / 20 - 50 °C

2: potassium osmate(VI) dihydrate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 0 °C

With potassium osmate(VI) dihydrate; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In water; acetonitrile; tert-butyl alcohol;

DOI:10.1002/cmdc.201000230

Reference yield:

(S)-2-(2-nitrobenzenesulfonylamino)butyric acid (686339-92-4) → (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide (1253798-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 5 h

2: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 4.5 h / 20 - 50 °C

3: potassium osmate(VI) dihydrate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 0 °C

With potassium osmate(VI) dihydrate; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In tetrahydrofuran; water; acetonitrile; tert-butyl alcohol;

DOI:10.1002/cmdc.201000230

upstream raw materials:

(S)-2-(2-nitrobenzenesulfonylamino)butyric acid

(S)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(2-nitrobenzenesulfonylamino)butyramide

(S)-2-[allyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

(3S,11bR)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-2-yl]acetamide

(1'R,3S,11bR)-2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline

(1'S,3S,11bR)-2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline

(S)-2-[N-(2-oxoethyl)-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1253798-50-3 (2'RS,2S)-2-[2,3-dihydroxypropyl-(2-nitrobenzenesulfonyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]butyramide

Send

Send

Metric Ton KG G Pound L ML

Send

Send