Isonicotinonitrile, 2-(2-hydroxyethyl)- (6CI)

Base Information

• Chemical Name: Isonicotinonitrile, 2-(2-hydroxyethyl)- (6CI)
• CAS No.: 106474-82-2
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Mol file: 106474-82-2.mol

Synonyms:Isonicotinonitrile,2-(2-hydroxyethyl)- (6CI)

Chemical Property of Isonicotinonitrile, 2-(2-hydroxyethyl)- (6CI)

Chemical Property:

• PSA: 56.91000
• LogP: 0.48808

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Hydroxyethyl)isonicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isonicotinonitrile, 2-(2-hydroxyethyl)- (6CI)

There total 3 articles about Isonicotinonitrile, 2-(2-hydroxyethyl)- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Cyano-2-pyridinecarboxaldehyde (116308-38-4) → 4-cyano-2-(2-hydroxy)-ethylpyridine (106474-82-2)

Guidance literature:

With hydrogenchloride; ammonium hydroxide; In tetrahydrofuran; methylmagnesium bromide;

Reference yield:

pyridine-4-carbonitrile (100-48-1) → 4-cyano-2-(2-hydroxy)-ethylpyridine (106474-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water

2: selenium(IV) oxide / 1,4-dioxane; dichloromethane

3: hydrogenchloride; ammonium hydroxide / tetrahydrofuran; methylmagnesium bromide

With hydrogenchloride; ammonium hydroxide; selenium(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; methylmagnesium bromide; water;

Reference yield:

4-cyano-2-hydroxymethylpyridine (51454-63-8) → 4-cyano-2-(2-hydroxy)-ethylpyridine (106474-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: selenium(IV) oxide / 1,4-dioxane; dichloromethane

2: hydrogenchloride; ammonium hydroxide / tetrahydrofuran; methylmagnesium bromide

With hydrogenchloride; ammonium hydroxide; selenium(IV) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; methylmagnesium bromide;

upstream raw materials:

4-Cyano-2-pyridinecarboxaldehyde

pyridine-4-carbonitrile

4-cyano-2-hydroxymethylpyridine

Refernces