51454-63-8

Basic information

• Product Name: 4-CYANO-PYRIDINE-2-METHANOL
• Synonyms: 4-CYANO-PYRIDINE-2-METHANOL;2-HYDROXYMETHYL-ISONICOTINONITRILE;4-CYNO-PYRIDINE-2-METHANOL;4-Cyano-2-(hydroxymethyl)pyridine;2-(hydroxyMethyl)-4-Pyridinecarbonitrile;2-(hydroxymethyl)pyridine-4-carbonitrile
• CAS NO: 51454-63-8
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• Mol File: 51454-63-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 282.4 °C at 760 mmHg
• Flash Point: 124.6 °C
• Appearance: /
• Density: 1.25 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.06±0.10(Predicted)
• CAS DataBase Reference: 4-CYANO-PYRIDINE-2-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-PYRIDINE-2-METHANOL(51454-63-8)
• EPA Substance Registry System: 4-CYANO-PYRIDINE-2-METHANOL(51454-63-8)

Safety Data

• Hazardous Substances Data: 51454-63-8(Hazardous Substances Data)

Usage

General Description

4-Cyano-pyridine-2-methanol, also known as 2-cyano-isonicotinic acid, is a chemical compound with the molecular formula C7H6N2O. It is a white to off-white crystalline powder that is used in the production of pharmaceuticals and agrochemicals. 4-CYANO-PYRIDINE-2-METHANOL is a key intermediate in the synthesis of various drugs, especially those that act on the central nervous system and cardiovascular system. It is also used as a building block in the manufacture of herbicides and insecticides. 4-Cyano-pyridine-2-methanol is an important chemical in the pharmaceutical and agrochemical industries, playing a crucial role in the development and production of various medicinal and agricultural products.

Upstream product

• 931-19-1 2-methylpyridine N-oxide 
• 2214-53-1 2-methyl-4-cyanopyridine 
• 98549-84-9 4-Cyano-2-picoline-N-oxide 
• 51454-62-7 2-acetoxymethyl-isonicotinonitrile 
• 67-56-1 methanol 
• 100-48-1 pyridine-4-carbonitrile 
• 7285-11-2 chloroform methanol 
• 7664-93-9 sulfuric acid 
• 2950-43-8 hydroxylamine-O-sulfonic acid 
• 30342-68-8 N-Ethoxy-2-picolinium iodide 
• 14906-59-3 4-cyanopyridine N-oxide 

Downstream Products

• 106474-82-2 4-cyano-2-(2-hydroxy)-ethylpyridine 
• 185220-30-8 2-(1'-hydroxyethyl)-4-acetylpyridine 
• 597563-02-5 2-(bromomethyl)isonicotinonitrile 
• 1201448-11-4 C₁₈H₁₇N₃O₄ 
• 1201446-08-3 (4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methanol 
• 1201446-41-4 N₁-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methyl)-N₂,N₂-diethylethane-1,2-diamine 
• 108337-75-3 2-(N-Benzyl-N-methylamino)ethyl Methyl 4-(4-Cyano-2-pyridyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 
• 116308-38-4 4-Cyano-2-pyridinecarboxaldehyde 

Relevant articles and documents

KCNT1 INHIBITORS AND METHODS OF USE

The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

AROMATIC RING COMPOUND

Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.

4-HETEROARYLMETHYL SUBSTITUTED PHTHALAZINONE DERIVATIVES

A compound of formula (I): for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NRx or CRxRy; if X=NRx then n is 1 or 2 and if X=CRxRy then n is 1; Rx is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ry is selected from H, hydroxy, amino; or Rx and Ry may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or when X is CRxRy, RC1, RC2, Rx and Ry, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R1 is selected from H and halo; and Het is selected from: (i) formula (i), where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N, where only one or two of Y1, Y2 and Y3 can be N; and (ii) formula (ii), where Q is O or S.