(2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

Base Information

Chemical Name:(2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate
CAS No.:228098-67-7
Molecular Formula:C₂₈H₂₇NO₄
Molecular Weight:441.527
Hs Code.:

Synonyms:(2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

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Chemical Property of (2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

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Technology Process of (2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

There total 3 articles about (2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 228098-63-3
(2R)-2-<2-(tert-Butyldimethylsiloxy)pyrrol-1-yl>-2-phenylethylbenzoate

: 228098-67-7
(2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

: (2R)-2-<(2S)-2,5-Dihydro-2-<(1S)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 3h; Yield given; Yields of byproduct given;
DOI:10.1055/s-1999-3434

Reference yield:

: 98-88-4
benzoyl chloride

: 228098-67-7
(2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / pyridine / 0.17 h / 0 °C

2: 88 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

With pyridine; boron trifluoride diethyl etherate; triethylamine; In dichloromethane;
DOI:10.1055/s-1999-3434

Reference yield:

: 228098-62-2
(2R)-2-(2,5-Dihydro-2-oxopyrrol-1-yl)-2-phenylethylbenzoate

: 228098-67-7
(2R)-2-<(2R)-2,5-Dihydro-2-<(1R)-1-hydroxy-3-phenylpropyl>-5-oxopyrrol-1-yl>-2-phenylethylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

With boron trifluoride diethyl etherate; triethylamine; In dichloromethane;
DOI:10.1055/s-1999-3434